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[17] (UK sample) reporting an effect size d = 2.6 for ACC glutamate difference between 1-month remitters and nonremitters, we required a sample of at least 22 patients to demonstrate 50% of the reported effect ( d = 1.3), with 5% type 1 and 20% type 2 error rates

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17 Oesophageal dysmotility is affected by acute glycaemic changes and is known to be suppressed by hyperglycaemia

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We can greatly decrease this by numbing the area prior to treatment