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Additionally, tirzepatide demonstrated improvements in cardiometabolic markers, including reductions in blood pressure and improvements in cholesterol profiles

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This allows for reactions with a broad spectrum of both physiological metabolites (such as estrogen, prostaglandins, and leukotrienes) and xenobiotics (including acetaminophen, persistent organic pollutants, and toxic metals such as mercury, arsenic, and lead)

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iPSC-derived microglia were obtained first from homogeneous and stable embryonic bodies (EB), and after 30 days, macrophage precursors were differentiated into microglia in the presence of IL-34, M-CSF, and TGF-1 (Reich et al., 2020)