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For gastrointestinal indications, systemic or oral administration is appropriate because the entire gut is the target

Reduced levels of tumor necrosis factor-alpha (TNF-) and MMPs indicated lower inflammation and enhanced tissue remodeling (Canapp et al., 2003)

GPs normally give these every 12 weeks, but the effects wear off before this and as a result the patient is left feeling sluggish and run down

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It is possible that the cumulative or progressive dosing regimen contributed to the outcome, particularly given that a dose of 10 mg/kg has been associated with adverse neurological effects in other experimental settings (Mohammadpanah et al., 2023