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Semaglutide works on the GLP-1 pathway
Mechanistically, spexin signals primarily through galanin receptor subtypes GALR2 and GALR3, receptors with complex roles in nociception, mood regulation, and metabolic control
The clinical relevance of age-related differences in gastrointestinal adverse events is an important consideration
"This work supports a shift away from prescribing testosterone replacement in men with obesity and low testosterone and toward treating the underlying cause excess weight and poor metabolic health which can naturally restore hormone levels and preserve fertility," she said in a statement released by the Endocrine Society
Feng et al., 2016) (Figure 2)
