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Initial therapy with the combination of JANUVIA and metformin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo, to metformin alone, and to JANUVIA alone (Table 8, Figure 1)

Clinical trials demonstrate significant weight reductiontypically 1015% of initial body weight over 68 weeks (STEP clinical trial programme)though many patients experience periods where weight loss slows or stops entirely, commonly termed a plateau

Understanding potential drug interactions with Zepbound is critical for patient safety and therapeutic efficacy

Precision-wellness approaches increasingly consider individual genetic predispositions in these receptor pathways to personalize treatment selection

Ana Lisa Carr (St