[7] [8] Symptoms include sudden pain in the upper right abdomen, fever, jaundice (yellowing of the skin or eyes), pale stools, or dark urine
Clinical trials have not identified heart failure as a significant adverse event, and the SUSTAIN-6 trial demonstrated cardiovascular benefits rather than harm
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Stapled truncated orexin peptides as orexin receptor agonists
Either way, the drug enters circulation gradually rather than all at once
Lancet , 398 (10300), 583598