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A multi-factorial approach was used in the study to establish a rat model of CAG, which were induced by combination administrations of sodium deoxycholate and ammonia coupled with starvation and fatigue

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Mechanism of action: melanocortin cAMP/PKA/MITF cascade Presynaptic activation of cutaneous MC1R and central MC3R/MC4R/MC5R PRIMARY PATHWAY MELANOGENESIS MC1R on melanocytes High-affinity binding to the MC1R receptor on epidermal melanocytes