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Surgical treatment may be indicated in resistant/intolerant patients and symptomatic apoplectic tumors

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GHK-Cu contributes copper-dependent collagen and extracellular-matrix synthesis, TB-500 contributes actin regulation and cell migration, and BPC-157 contributes angiogenesis and cytoprotection, while KPV, the C-terminal tripeptide of alpha-MSH, contributes suppression of NF-kB-driven inflammatory signalling without melanocortin-receptor pigmentation effects