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The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide

In this study, nearly a third of patients lost 25% or more of their starting weight on the higher dose of semaglutide, compared with only 15% who lost that amount on 2.4 mg and none on the placebo

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FIGURE 1 The mechanism of GLP-1 RAs, however, is now understood to extend far beyond glucose control, offering powerful dual central and peripheral action

Richard Jadick in LaGrange

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