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Peer review Peer review information Nature Reviews Nephrology thanks Reza Abdi, who co-reviewed with Vivek Kasinath, Kanyi Pu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Additional information Publishers note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

Each cycle of loss and regain may worsen metabolic adaptation, making subsequent weight loss harder and regain faster

Pure tirzepatide solutions without B12 appear clear or slightly opalescent

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities