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Glutamate dehydrogenase and glutamate production The evidence that glutamate may serve as a second messenger to amplify insulin secretion comes from identifying a gain-of-function mutation in the gene encoding glutamate dehydrogenase (GDH), an enzyme that catalyses conversion of -ketoglutarate to glutamate

Subgroup analysis was introduced by subdividing RCTs according to whether the peripheral neuropathy diagnosed in patients was diabetic or non-diabetic

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