Anecdotal reports include mild lethargy or head-pressure during loading phases, but these are not RCT-verified
Dose: SC injection of 250 g per injection in cats and, 250-1500 g per injection in dogs, depending on the size of the patient: *Information provided by Texas GI Lab* Northland Veterinary Services8560 Topper RoadIron River, WI 54847(715)372-5590
(the significance of a high cobalaminconcentration in blood) Ermens AAM, Vlasveld LTh, Van Marion-Kievit JA, Lensen CJPA, Lindemans J
further notes that NICE CKS guidance states that treatment of B12 deficiency in people with neurologic involvement should include injections on alternate days until there is no further improvement
NNMT nicotinamide N-methyltransferase, Gene ID 4837 (11q23.2, 8 exons, EC 2.1.1.1)
Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls