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To clarify gut microbiota interventions' efficacy in alleviating depressive symptoms, researchers did systematic reviews and meta-analyses, including RCT on probiotics, prebiotics, synbiotics or fecal microbiota transplantation in adults (18 years) that used validated, placebo-controlled measures to assess depressive symptoms

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And the mRNA expression levels of SIRT1, PGC-1, and PEPCK in the liver of the mice were significantly increased

Each of these multiple reactions require a specific enzyme, thus conversion is a complex process, even for a healthy person

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