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The potential metabolism-immune-neuro interaction framework of PEM is based on multi-level molecular crosstalk: mitochondrial dysfunction generates DAMPs that activate innate immune pathways (NLRP3, NF-B) to induce peripheral inflammation

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Intra-articular injection of monoiodoacetate induces diverse hip osteoarthritis in rats, depending on its dose

BrimbleKSGanameJMargettsPJainAPerlJWalshMet al

Dimensions: 5100 x 3387 px | 43.2 x 28.7 cm | 17 x 11.3 inches | 300dpi Date taken: 2008 Location: Northern Ireland, UK

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