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There is no weight requirement to define obesity

This observed increase may reflect the high prevalence of metabolic comorbidities among patients with PCOS, rather than expanded prescribing of GLP-1s specifically for PCOS

However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development

As Case 2 demonstrated, a patient may tolerate one drug in the class (semaglutide) but not another (tirzepatide), suggesting the reaction may be specific to certain agents or their unique pharmacologies

Interestingly, overexpression of PNPLA2 does not increase serum FAs or promote the ectopic deposition of TAGs

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