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The privately held company first filed for approval of the drug in September 1999 but the New Drug Application was rejected by the FDA in 2002

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The energy necessary for the transport of these neurotransmitters into the secretory vesicles is provided by the proton gradient generated by the vacuolar H + -ATPase (V-ATPase)

186 This suggests that targeting USP20 may mitigate chemotherapy resistance and promote ferroptosis in HCC patients, and explains why DNA damage therapy often leads to treatment resistance