glp 1 agonists vs sglt2 inhibitors Frontiers GLP-1 receptor agonists vs. SGLT-2

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164 Both the paralogous transcriptional co-activators contain highly conserved modular structure that encompasses an acetyltransferase domain, acetyl lysine-binding bromodomain (BD) and diverse structured modules like KIX domain, the cysteine/histidine regions (TAZ1 and TAZ2), the interferon response binding domain (iBID) and the nuclear receptor interaction domain (RID)

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Their structural components include the outer mitochondrial membrane (OMM), inner mitochondrial membrane (IMM), mitochondrial matrix, and intermembrane space (IMS) (Wang et al., 2024)

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