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Follow the clinical plan and the vial label after opening, especially with multi-dose vials

However, in the 25 to 33% of patients who experience shunting with thiopurine monotherapy (preferential metabolism to less effective and potentially toxic thiopurine metabolites), low doses of thiopurines in combination with allopurinol may be prescribed to improve therapeutic effect

Prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)

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Some people feel improvement in fatigue sooner, but blood markers and neurologic symptoms may take longer to assess