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Some people achieve their goals at 10 mg or 12.5 mg and see no reason to push higher

Moreover, hydrolysis and first-pass metabolism by the intestinal microbiota also reduce its systemic levels (Wang et al., 2014)

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Trials should also incorporate sex-specific analyses, age related stratification, and clinically relevant comorbidities such as gastrointestinal dysfunction and sleep problems, all of which can modulate treatment efficacy