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ICEs defined in the GEMINI-1 protocol are premature discontinuation of treatment and use of drugs or therapies with a substantial effect on body weight before reaching the primary endpoint

Half-life differences mean that stacking is rarely as simple as mixing two compounds in one syringe

Glycosylation sites are shown in grey

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Notably, the observed variability in efficacy between agents, particularly in the early phases of treatment, emphasizes the importance of individualized therapeutic strategies, tailored to specific clinical goals, baseline metabolic profiles, and patient preferences