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As of early 2026, more than 45 pharmaceutical companies across India, China, South Korea, and Europe have initiated active development programs for generic or biosimilar semaglutide formulations, intensifying competition for high-purity API supply and placing significant upward pressure on capacity investments across both synthetic chemical synthesis and recombinant biotechnological production pathways

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Irregular eating or skipping meals can cause fluctuations in blood sugar, impacting how semaglutide works

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Employer Strategies SmithRx Key Takeaways GLP-1 demand has exploded for diabetes/weight loss, creating shortages and huge pharmacy spending that can force employers to raise premiums or cut coverage