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We discuss how effortful foraging for information, undistracted reflection and physical exercise are ways to invest and therefore grow our levels of dopamine, energy and motivation, whereas low-friction activities are specifically designed to hijack or diminish them

This could be due to enhancement of hepatic amino-acid catabolism with hepatic glucagon receptor activation

First, ROS directly modifies ion channels, oxidizing sulfhydryl groups on voltage-gated Na+ channels, resulting in abnormal action potential propagation and contributing to the paradoxical coexistence of pain and numbness (Pop-Busui et al., 2016)

Sci Rep 6:31119

It would be great if there were large-scale trials to test this idea out more legitimately

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