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doi: 10.1016/S0924-2244(98)00027-2

This layered approach allows patients to capture both systemic and local benefits while managing cost and convenience

The maximum concentrations (C max ) of each dose were 12.3, 48.9, and 141 ng/ml, respectively, and the AUC 0t values were 75.1, 289, and 1930 ng min/ml, respectively

Larger jumps risk triggering intolerance that wouldn't occur with gradual progression

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