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Precise control of operational parameterssuch as power, temperature, and extraction durationis essential, as excessive energy input or prolonged treatment can degrade sensitive polyphenolic structures, potentially lowering yield or altering compound profiles ( 3.1.4 Supercritical fluid extraction method Supercritical fluid extraction is an alternative two-step technique

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Variants in FTO (fat-mass and obesity-associated), MC4R (a receptor central to satiety and energy balance), GLP1R (the GLP-1 receptor targeted by these compounds), and TCF7L2 (a glucose-homeostasis factor) shape the metabolic starting line