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Age-related reductions in reproductive hormone levels, testicular function, chromosomal integrity, and sperm health, as well as increased oxidative stress and cumulative damage to sperm DNA, all contribute to reduced fertility

10.1038/s41388-024-03057-6 148 ZhouG.MengS.LiY.GhebreY

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Notably, predictive models derived from features selected from the NS5B and E1 regions tended to have more predictive power than those from more conserved regions such as 5' NCR and CORE

This phenomenon was associated with the AMPK and acetyl-CoA carboxylase signaling pathways

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