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Both agents affect glucose homeostasis, albeit differently
IV delivery maximizes effectiveness : Intravenous administration achieves 100% bioavailability compared to oral supplements' 2-10% absorption rate for both compounds
Mechanistically, in macrophages, GLP-1RAs directly ameliorate NF-B activation, thereby improving insulin resistance [132]
How GLP-1s Affect Appetite When You Have Type 2 Diabetes GLP-1 medications work similarly in people who are taking them for type 2 diabetes as they do in people taking them for weight loss, although the research is still ongoing, says Jennifer Nasser, PhD, RD, an associate professor of nutrition sciences at Drexel University in Philadelphia and spokesperson for the Obesity Society