Reduced adipose tissue oxygenation contributes to IR by decreasing branched-chain amino acid catabolism and increasing plasma branched-chain amino acid concentrations [44]
Instead of oral glutathione, consider N-acetylcysteine (600mg twice daily), which provides the cysteine substrate for hepatic glutathione synthesis and has documented hepatoprotective effects in acetaminophen toxicity and non-alcoholic fatty liver disease
Not everyone experiences significant facial volume loss, but it is common among patients who lose weight rapidly or who lose a substantial percentage of body weight
In this context, fibroblast growth factor 21 (FGF21) analogues are attractive because they target multiple components of MASH biology simultaneously, with potential to improve steatosis, inflammation, fibrosis, and broader cardiometabolic risk
My heart goes out to all the friends and family and collaborators lucky enough to be in his orbit
FAMILY HISTORY: Provide prevention measures for patients with family history of common chronic disease conditions
