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[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

Administered as a once-weekly injection, Ozempic helps lower blood glucose levels by stimulating insulin production and reducing glucagon secretion

Genetic and pharmacologic studies in mice support this framework, although receptor specificity and downstream signaling remain areas of active investigation

Ettinger 1997

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