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The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

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However, the best results typically develop over the course of 3 to 6 months

doi: 10.1126/science.194.4269.1027

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SNAC-based oral semaglutide must be taken fasting with plain water specifically because food dramatically reduces absorption