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A critical gap is the identification of definitive molecular switches that determine whether the crosstalk promotes tumor cell survival or death in a given therapeutic setting, which severely impedes the rational design of pathway-specific modulators

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), so the key is targeted organ cooling (like cold perfusion for transplants or topical cooling of the heart/brain)

10.1517/14728220802705696 50 JureczekJ.BergmannR.BerndtN.KoristkaS.KeglerA.Puentes-CalaE.et al (2019)

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Published March 5, 2024