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The lymphocyte co-stimulatory cascade was identified as the underlying molecular pathway and was blocked at several points with monoclonal antibodies, pointing towards novel therapeutic approaches, some of which are now in clinical trials

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This review focuses on one over looked neurotrophin, hepatocyte growth factor (HGF) that acts via the Type 1 tyrosine kinase receptor Met to mediate stem cell differentiation, synaptogenesis, neurogenesis, and protect against tissue insults in a wide range of cell types including neurons

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