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Rat ghrelin was kindly provided by Dr

Work closely with your healthcare provider to assess the effectiveness of the treatment and make any necessary adjustments

Assessment of Cell Viability ARPE-19 cell viability was evaluated by performing the 3-(4,5-dimethylthiazol-2-yl)5-(3-carboxymethoxyphenyl)2-(4-sulfophenyl)2 H-tetrazolium (MTS) assay as previously described [25]

Howe CL, Mayoral S, Rodriguez M

Taking into account that reactive astrocytes may produce various neurotrophic factors and antioxidant molecules targeting neuronal survival, it is possible that genetic manipulation of these functions in astrocytes may represent a promising strategy to improve dopaminergic neurons or neural progenitor cells survival [4,23]

Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs