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doi: 10.1038/s41591-022-02026-4

Ryan Mulcunry, David Seiden, Jennie Kim, Nick Disimile, Akilah MooreGA Group GA Group 1yDave Wisniewski reposted thisB

They are "left-handed" enantiomers, which refers to the stereoisomers of the alpha carbon

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Maneiros team employed copper-free click chemistry (SPAAC) to conjugate the BRD4 degrader ARV-771 to trastuzumab, yielding a HER2-targeting DAC that exhibited selective BRD4 degradation and robust stability in HER2 + cells [217]