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The weight loss it produces is maintained while on treatment

The goal is to identify and reduce foods that trigger symptoms whilst maintaining adequate nutrition for weight management

Tendon Research, 23(5), 374-380

however, metformin is associated with failure in glycaemic control in approximately half of adolescents 13 , and insulin is associated with hypoglycaemia and weight gain 4,5

Methodologically akin to a retrospective cohort analysis, our study differs in that it emulates a target trial by prespecifying the protocol, aligning index date, and using propensity score matching to emulate randomization, thereby reducing immortal-time bias, improving transparency, and aligning real-world evidence generation with clinical trial standards