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Shedding on this pattern tends to start a few months into treatment and settle as weight steadies

The test reveals predispositions in GLP1R, GIPR, and metabolic pathways that may influence how your body responds to GLP-1 therapy

49 It is interesting that the double Aib substitutions led to comparable receptor binding and potency (IC 50 = 1.1 nM, EC 50 = 0.06 nM compared to GLP-1 (IC 50 = 1.5 nM, EC 50 = 0.08 nM)), whereas a single Aib at position 8 brought in a 4-fold decrease in potency and 2-fold increase in binding affinity

Practical Takeaways There is some limited evidence supporting AOD 9604s impact on lipid metabolism, suggesting its potential to induce weight loss, specifically in animal models

Washbourne P, Bennett JE, McAllister AK