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doi: 10.1093/database/baab007

Therapeutic & Research Applications FDA-Approved Indications: Growth hormone deficiency (pediatric and adult), Turner syndrome, chronic renal insufficiency, Prader-Willi syndrome, SGA (small for gestational age), and AIDS-related wasting

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Medina-Franco JL, Giulianotti MA, Welmaker GS, Houghten RA

Hasek, B

Receptor activation In spite of various conformational changes upon ligand binding, signaling initiation by either peptidic or small molecule agonists shares a common pathway, i.e ., reorganization of the central polar network, HETX motif and TM2-6-7-helix 8 polar network, as well as the hallmark outward movement of TM6 (ref