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In its warning, the FDA said that some users of compounded products ended up needing hospital care due to dosing errors related to confusion over units of measurement, fluctuating product concentrations and the use of multiple-dose vials

Graham Lipkin, a Consultant Nephrologist at Queen Elizabeth Hospital Birmingham, highlights this risk: "Some of the side effects of GLP-1 medicines include dehydration, which can result in acute kidney injury (AKI)

Cui et al

Dysesthesia in up to 20.9% of patients and an 11.3% discontinuation rate in the general obesity population are real clinical concerns the FDA will weigh carefully

In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]

But before drawing any conclusions, there's a question that almost never gets asked first: how hydrated were you when that blood was drawn