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Early-phase clinical trials have reported substantial reductions in body weight (Jastreboff et al., New England Journal of Medicine , 2023)

Many are concerned about how GLP-1 therapy could affect testosterone, fertility, muscle preservation, and sexual health

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Tesamorelin also supports muscle preservation through GH and IGF-1 elevation, potentially counteracting the lean mass loss associated with aggressive weight loss peptide protocols

However, GPR40 but not GPR120 knockout mice exhibit impaired GLP-1 secretion from dietary fat, and only GPR40 agonists induce GLP-1 release in vitro and in vivo 106,110,111,112

Glossary of Key Terms GLP-1 (Glucagon-Like Peptide-1) A hormone produced in the intestines that slows gastric emptying, increases insulin secretion, and reduces appetite