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DISCUSSION CONFLICTS OF INTEREST Hideaki Jinnouchi has received honoraria from Novo Nordisk, Sanofi, Eli Lilly, Mitsubishi Tanabe Pharma, and Otsuka Pharmaceutical

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The enzyme samples were then incubated with approximately 510 5 cpm 125 I-insulin for 5 minutes at 37C, and then applied directly to a reversed-phase HPLC column, similar to that previously described [26]

The remaining three studies reported no significant improvements in UPDRS scores