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GOT2 has been identified as playing a pivotal role in pancreatic cancer, modulating the immune microenvironment and suppressing anti-tumor immune responses

CSCs can consume metabolites within the TME

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At the heart of SFNs anti-CSC activity lies its coordinated interference with Wnt/-catenin, Notch, and Hedgehog signaling - three evolutionarily conserved pathways that frequently become dysregulated in CSCs

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