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Two months course( 16 injections)

Oridonin, a diterpenoid compound isolated from Rabdosia rubescens , was shown to alleviate PI-IBS symptoms in rats by significantly inhibiting phosphorylation of NF-B p65 and downregulating downstream inflammatory mediators such as inducible nitric oxide synthase (iNOS), COX-2, IL-1, and IL-6

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Gorca & Asanowicz-Antkowiak [104] found that ALA (60 mg/kg, IV) increased brain-SH groups in LPS-treated rats, demonstrating ALAs potential to limit nerve tissue damage from oxidative stress

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However, there are limited established methodologies and protocols for reusing SSS, and its dynamics are not fully understood [8]