Additionally, patients who stop taking the medications often regain the weight they lost even with diet and exercise
Specifically, gut microbiota dysbiosis, such as increased abundance of Proteobacteria and Actinobacteria and decreased numbers of Bacteroidetes , Prevotella and Firmicutes phyla , reduces the expression of tight junction protein genes, directly leading to the impairment of intestinal barrier function, making harmful microbiota and microorganisms pass through the intestinal barrier, stimulating the immune system and inducing immune cell inflammation, and ultimately accelerating NAFLD and liver fibrosis (58, 59)
Nat Protoc 8 , 16601669 (2013)
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PMID 8307579
