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This lipid overload renders hepatocytes vulnerable to oxidative injury through enhanced generation of reactive oxygen species (ROS), mitochondrial respiratory dysfunction, and endoplasmic reticulum stress

Recently, Zynteglo (betibeglogene autotemcel), a gene therapy for -thalassemia, received conditional market approval in Europe [111,112]

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Our exclusion criteria comprised non-original designs, studies investigated on internal GLP-1, studies lacking weight change outcomes, studies without all population undergoing bariatric surgery, absence of baseline patient characteristics