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Additionally, these agents suppress glucagon secretion, slow gastric emptying, and act on central appetite centers in the brain to increase satiety and reduce food intake
cAMP signalling in insulin and glucagon secretion
The ACC document, which was endorsed by the American Diabetes Association (ADA), outlined a variety of considerations for use of these agents in patients with ASCVD, including considerations that may warrant selection of either a GLP-1 RA or an SGLT-2 inhibitor for cardiovascular risk reduction ( Table 1 )
It can also mean staying at low doses of a drug for a long period, instead of titrating up to standard maintenance levels
GLP-1 medications may contribute to nausea, constipation, and dehydration, making hydration important for digestion and overall well-being
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