tirzepatide for minor weight loss FDA Grants a New Indication Obesity Management Your First 3 Months on

(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)

PIONEER 3: Head-to-head vs Januvia (sitagliptin) 1,4 Study design: 78-week, randomized, double-blind, double-dummy, active controlled, parallel-group, phase 3a trial designed to assess the efficacy and assess long-term adverse event profile of once-daily semaglutide tablets vs Januvia in addition to metformin with or without sulfonylurea

They are life long, and so we need to continue to reach out to different communities to reinforce that message

A recent review (funded by an L-carnitine manufacturer) proposed that TMAO is the result of an already present injury and is not causative

Three key takeaways Tooth decay affects just under half of adults with natural teeth , but it's mostly preventable with the right habits

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