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The Plavix cliff also illustrated the paragraph IV lottery dynamic: generic companies that successfully challenge a patent before expiry can be rewarded with 180-day exclusivity the period during which only they and the innovator (via AG) can sell the drug

The Tepezza lawsuit claims that Horizon Therapeutics failed to warn patients about the potential risks and side effects of the drug, leading to hearing loss and other problems, such as tinnitus

Researchers at the University of Helsinkis OBRAIN Lab, in collaboration with the Montreal Neurological Institute, examined data from approximately 30,000 middle-aged adults in the UK Biobank

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If side effects are problematic, dose adjustment or alternative management strategies can often be implemented