The combination of 1 mM metformin with both 10 nM semaglutide and 10 nM tirzepatide improves the effects of 10 nM semaglutide and 10 nM tirzepatide on cellular apoptosis, dysregulated cell cycle, and impaired function in HG-HL-induced INS-1 -cells
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L cells express the surface receptor TGR5, and TGR5 agonists such as 6-ethyl-23(S)-methylcholic acid (EMCA, INT-777) can induce GLP-1 release, modulating insulin secretion and delaying gastric emptying
European Journal of Neurology 31(5):e16238
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