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~H NMR, 60 MHz, D20, 6 ppm: 6.08 (s, 2 H, CH 2 ), 7.56 (s, 5 H, ~b), 7.939.22 (m, 4 H, pyr

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Here, we propose the Organelle Interaction Network Disruption Model of ovarian aging, which integrates recent mechanistic insights into a unifying conceptual framework

Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies