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qRT-PCR The mRNA levels of Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 were quantified by qRT-PCR using the cortex of the WT, control, (-)-Vestitol, Salviolone, and combination groups ( n = 3 per group, randomly selected)
Due to insufficient NADPH, G6PD-deficiency leads to a switch of the biosynthetic pathway for GSH, thus limiting AMPK activation (62)
Together, these findings suggest that G/D-CuP promotes macrophage polarization toward the M2 phenotype, thereby reducing inflammation, enhancing antioxidant capacity, and ultimately accelerating effective wound healing
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