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Furthermore, chronic inflammation is recognized as a key factor in inducing insulin resistance, and GPER can modulate intracellular signaling pathways or suppress the expression of proinflammatory cytokines, which reduces the interference of chronic inflammatory responses and improves insulin resistance [1, 34]
It effectively upregulates GSTM1 and blocks interleukin (IL)-8, granulocyte-macrophage colony-stimulating factor (GMCSF), IL-1 production in the bronchial epithelial cells [91]
In studies, reactions were reported in 1.4% of Wegovy-treated patients and 1.0% of placebo-treated patients
These require prompt medical evaluation
Additionally, at the policy level, strengthen support measures for vulnerable groups, such as targeted service provision and precise resource allocation, to lower barriers to accessing public resources